abstract：BACKGROUND/AIM:Over the past 15 years, there were considerable changes in factors associated with the development and treatment of upper gastrointestinal symptoms, of which the introduction of proton pump inhibitors and Helicobacter pylori eradication in guidelines for treatment of patients with dyspepsia are the most ...

journal_title：Digestion

authors： van Kerkhoven LA,van Rijswijck SJ,van Rossum LG,Laheij RJ,Witteman EM,Tan AC,Jansen JB

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) results from an aberrant immune response to the indigenous intestinal flora in genetically susceptible hosts. Therefore, the study of candidate genes involved in host pathogen interactions is of key interest. METHODS:In this two-center, retrospective German and Hungarian coh...

journal_title：Digestion

authors： Baumgart DC,Buning C,Geerdts L,Schmidt HH,Genschel J,Fiedler T,Gentz E,Molnar T,Nagy F,Lonovics J,Lochs H,Wiedenmann B,Nickel R,Witt H,Dignass A

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND/AIMS:The changes in gastroesophageal reflux disease (GERD)-related symptoms on treatment are variously described, but currently available questionnaires have shortcomings. We therefore developed a self-assessment reflux questionnaire (ReQuest). This article describes the process of development and testing. ...

journal_title：Digestion

authors： Bardhan KD,Stanghellini V,Armstrong D,Berghöfer P,Gatz G,Mönnikes H

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Inflammatory diarrhoea (ID) resulting from Shigella, Salmonella, Campylobacter and Entamoeba histolytica requires specific diagnosis for therapy. Differentiation between ID and non-inflammatory diarrhoea (NID) is often not clinically possible. A faecal occult blood test (FOBT) correlates with faecal leucocyt...

journal_title：Digestion

authors： Ashraf H,Beltinger J,Alam NH,Bardhan PK,Faruque AS,Akter J,Salam MA,Gyr N

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:To carry out a preliminary epidemiological investigation of Yersinia enterocolitica from a clinical perspective in China and to further validate the consistency of real-time polymerase chain reaction (RT-PCR) and culture method. METHODS:700 stool samples were randomly and continuously collected from in- and ...

journal_title：Digestion

authors： Zheng H,Wang J,Sun Y,Jiang B

更新日期：2007-01-01 00:00:00

abstract：:Malabsorption syndromes are commonly caused by pathological interferences of normal digestive processes. In the last several years major advances in the diagnosis and treatment of these syndromes has emerged. This review will focus on diseases in which the mucosal phase of the digestive process is predominately distur...

journal_title：Digestion

authors： Sun DF,Fang JY

更新日期：2006-01-01 00:00:00

abstract：:Leukocytapheresis has recently been used to induce remission in patients with ulcerative colitis (UC) who fail to respond to corticosteroids. We could not find a report in the literature on leukocytapheresis for UC with gestational exacerbation. We have recently encountered this unique condition and report the details...

journal_title：Digestion

authors： Okada H,Makidono C,Takenaka R,Hiraoka S,Fujiwara A,Kato J,Kawahara Y,Kawamoto H,Mizuno M,Shiratori Y

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The incidence of esophageal cancer is markedly increased in patients with head and neck cancer, and the presence of esophageal cancer is associated with reduced survival rates. AIMS:We investigated whether the results of screening for esophageal cancer in patients with head and neck cancer using chromoendos...

journal_title：Digestion

authors： Moschler O,Spahn TW,Middelberg-Bisping C,Grosse-Thie W,Christoph B,Kloeppel G,Mueller MK

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND/AIMS:As opposed to regular C-reactive protein (CRP) assays, the introduction of high-sensitivity ones has enabled us to detect low grade inflammation in patients with inflammatory bowel disease (IBD). We addressed the subject of the degree of correlation between the concentration of high-sensitivity CRP (hs-...

journal_title：Digestion

authors： Zilberman L,Maharshak N,Arbel Y,Rogowski O,Rozenblat M,Shapira I,Berliner S,Arber N,Dotan I

更新日期：2006-01-01 00:00:00

abstract：:Functional digestive disorders constitute one of the main causes of consultation in gastroenterology and primary health care. Is still unclear whether therapy has to be aimed to the gut, to the neural pathways controlling bowel motility and perception, or to the processing mechanisms of symptoms and disease behaviour....

journal_title：Digestion

authors： Mearin F

更新日期：2006-01-01 00:00:00

abstract：:After two decades of progress the best current approach to treatment of Helicobacter pylori infection is a strategy that combines two consecutive complementary treatments. Current guidelines recommend a first-line triple therapy - 7-10 days of a proton-pump inhibitor (PPI), clarithromycin and amoxicillin - followed by...

journal_title：Digestion

authors： Calvet X

更新日期：2006-01-01 00:00:00

abstract：:Previous investigations have demonstrated that the cellular signaling induced by hypoxia-reoxygenation is a major pathway contributing to gastric mucosal injury induced by stress, non-steroidal anti-inflammatory drugs, and Helicobacter pylori. The aim of the present study was to perform a gene expression analysis of t...

journal_title：Digestion

authors： Katada K,Naito Y,Mizushima K,Takagi T,Handa O,Kokura S,Ichikawa H,Yoshida N,Matsui H,Yoshikawa T

更新日期：2006-01-01 00:00:00

abstract：:At 1 year after a first resection, up to 80% of patients show an endoscopic recurrence, 10-20% have clinical relapse, and 5% have surgical recurrence. Smoking is one of the most important risk factors for postoperative recurrence. Preoperative disease activity and the severity of endoscopic lesions in the neoterminal ...

journal_title：Digestion

authors： Froehlich F,Juillerat P,Felley C,Mottet C,Vader JP,Burnand B,Michetti P,Gonvers JJ

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Capsule endoscopy (CE) has been recognised as an important investigational tool in the diagnosis of gastrointestinal disease. Studies have shown that CE can identify lesions in the upper gastrointestinal tract as well as in the small intestine. However, contrary to conventional oesophagogastroscopy ...

journal_title：Digestion

authors： Peter S,Heuss LT,Beglinger C,Degen L

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AND AIMS:To evaluate genotyping for two DNA variants (c.1993+327C>T and c.1438+117G>A), recently found to be associated with adult-type hypolactasia, in the diagnosis of lactose intolerance. METHODS:In total, 166 consecutive patients with gastrointestinal symptoms mimicking hypolactasia admitted to the clin...

journal_title：Digestion

authors： Büning C,Genschel J,Jurga J,Fiedler T,Voderholzer W,Fiedler EM,Worm M,Weltrich R,Lochs H,Schmidt H,Ockenga J

更新日期：2005-01-01 00:00:00

abstract：:In 1905, John Edkins (1863-1940) undertook the studies of gastrin that have subsequently formed the basis for a century of investigation into the physiological basis of acid secretion and led to the elucidation of a variety of acid-suppressive pharmacological agents that have revolutionized the management of acid pept...

journal_title：Digestion

authors： Modlin IM,Sachs G,Wright N,Kidd M

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Autoimmune enteropathy (AIE) is a rare cause of intractable diarrhea in infancy. A variant with onset in adulthood has recently been described. The immune mechanisms underlying AIE are unclear and the experience in the management of adult AIE is very limited. CASE REPORT:A 19-year-old male patient with ma...

journal_title：Digestion

authors： von Hahn T,Stopik D,Koch M,Wiedenmann B,Dignass A

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND/AIMS:The mitogenic signaling pathway of epidermal growth factor receptor (EGFR) is activated in a variety of cancers, including hepatocellular carcinoma (HCC). The recently cloned EGFR-related protein (ERRP) has been proposed to be a negative regulator of EGFR. The expression of ERRP in non-malignant liver c...

journal_title：Digestion

authors： Moon WS,Chang KJ,Majumdar AP,Tarnawski AS

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND/AIMS:Evaluation of the response of gastroesophageal reflux disease (GERD) symptoms to treatment would be facilitated by a brief, valid, reliable and responsive, self-assessed GERD-sensitive scale. We therefore developed the Reflux Questionnaire (ReQuest). This publication describes the psychometric evaluatio...

journal_title：Digestion

authors： Mönnikes H,Bardhan KD,Stanghellini V,Berghöfer P,Bethke TD,Armstrong D

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND/AIMS:Transgenic mice overexpressing hepatitis B x protein (HBx) show an increased susceptibility to mutations if exposed to mutagens. Also involved in HBx signalling, reactive oxygen intermediates (ROI) can induce DNA adducts such as 8-hydroxy-2'-deoxyguanosine that can in turn lead to G/T transversion mutat...

journal_title：Digestion

authors： Gehrke R,Brauchle MA,Reifenberg K,Hildt E,Gruetzner U,Schmitz V,Schlicht HJ,Hofschneider PH,Caselmann WH,Rabe C

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVES:Few prospective population-based studies have been carried out on the incidence of inflammatory bowel disease (IBD). In a population-based study of pediatric IBD in southeastern Norway, patients <16 years at the time of diagnosis were followed up prospectively. The study reports on changes in diagnosis and c...

journal_title：Digestion

authors： Størdal K,Jahnsen J,Bentsen BS,Moum B

更新日期：2004-01-01 00:00:00

abstract：:Gastro-oesophageal reflux disease (GORD) is a chronic illness causing recurrent typical and atypical symptoms. Possible complications include oesophagitis, ulcer, stricture and Barrett's oesophagus. Evidence suggests that the intraoesophageal pH correlates directly with the degree of mucosal injury. Proton pump inhibi...

journal_title：Digestion

authors： Savarino V,Dulbecco P

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND/AIMS:Grading gastric mucosal atrophy in antrum biopsy specimens remains a controversial subject because of limitations in interobserver agreement. We previously described a reliable, quantitative method for grading atrophy of the corpus mucosa with excellent reproducibility and good correlation with the Sydn...

journal_title：Digestion

authors： van Grieken NC,Meijer GA,Kale I,Bloemena E,Lindeman J,Offerhaus GJ,Meuwissen SG,Baak JP,Kuipers EJ

更新日期：2004-01-01 00:00:00

abstract：AIM:Although pectin, a dietary fibre, has been suggested to possess some trophic effects on the intestine, the mechanisms involved remain unclear. This study aimed to evaluate the effects of pectin on rat intestinal cell proliferation and the intraluminal environment. METHODS:Control and pectin-fed rats were given a f...

journal_title：Digestion

authors： Fukunaga T,Sasaki M,Araki Y,Okamoto T,Yasuoka T,Tsujikawa T,Fujiyama Y,Bamba T

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Different food items are made responsible for irritable bowel syndrome (IBS) symptoms, but the physiopathology of IBS remains unclear. AIMS:During a meeting in Nice, France, experts of the European Working Team of the IBiS Club discussed selected data regarding the relationships between alimentation, food i...

journal_title：Digestion

authors： Dapoigny M,Stockbrügger RW,Azpiroz F,Collins S,Coremans G,Müller-Lissner S,Oberndorff A,Pace F,Smout A,Vatn M,Whorwell P

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND/AIMS:In the human stomach various alcohol dehydrogenase (ADH) isoenzymes exist. The gastric ADH activity is affected by a number of factors including also the infection of Helicobacter pylori. The objective was to investigate the activity of alcohol dehydrogenase isoenzymes of class I, III and IV in endoscop...

journal_title：Digestion

authors： Chrostek L,Jelski W,Szmitkowski M,Laszewicz W

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND/AIM:Studies have demonstrated an important role for endogenous PG and NO in the healing of chronic gastric ulcers. We investigated the effects of COX and NOS inhibitors on the healing of duodenal ulcers, in comparison with gastric ulcers, in rats. METHODS:Gastric and duodenal ulcers were induced by serosal ...

journal_title：Digestion

authors： Araki H,Komoike Y,Matsumoto M,Tanaka A,Takeuchi K

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Supramaximal concentrations of cholecystokinin (CCK) or cerulein induce the intracellular activation of trypsinogen and the transcription factor NF-kappaB, a key regulator of inflammatory gene expression. Both events occur early in the development of an acute pancreatitis. The aim of this study was ...

journal_title：Digestion

authors： Tando Y,Algül H,Schneider G,Weber CK,Weidenbach H,Adler G,Schmid RM

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Leptin is a pleiotropic hormone that is involved in the regulation of food intake and body weight. Recent findings demonstrated that leptin receptors are present in the pancreas but the involvement of leptin in pancreatitis remains unknown. The aim of the present study was: (1) to assess plasma leptin levels...

journal_title：Digestion

authors： Konturek PC,Jaworek J,Maniatoglou A,Bonior J,Meixner H,Konturek SJ,Hahn EG

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Somatostatin and its analogues have antitumor effects on foregut and midgut neuroendocrine (NE) tumors, but their effect on hindgut NE tumors is unclear. We examined the effect of the somatostatin analogue, octreotide, on human rectal NE carcinoma. MATERIALS AND METHODS:Expression of somatostatin receptor (...

journal_title：Digestion

authors： Koizumi M,Onda M,Tanaka N,Seya T,Yamada T,Takahashi Y

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND/AIM:Diarrhoea in collagenous colitis has been considered as secretory though the pathophysiology has been studied thoroughly in only a few patients. The result of fasting is one way to distinguish between secretory and osmotic diarrhoea. Our aim was to investigate the effect of fasting on diarrhoea in collag...

journal_title：Digestion

authors： Bohr J,Järnerot G,Tysk C,Jones I,Eriksson S

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND/AIM:Cutaneous electrical stimulation has been reported to be as effective as electroacupuncture. The aim of this study was to test whether cutaneous electrical stimulation had the same effect as electroacupuncture to enhance the regularity of myoelectrical activity. METHODS:Fifteen healthy male volunteers w...

journal_title：Digestion

authors： Chang CS,Chou JW,Ko CW,Wu CY,Chen GH

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of this study was to exactly determine the pH stability of human gastric lipase (HGL) and to investigate the mechanism underlying the inactivation of HGL which occurs in gastric juice. METHODS:Samples of human gastric juice and purified HGL were incubated at various pH values ranging from 0.5 t...

journal_title：Digestion

authors： Ville E,Carrière F,Renou C,Laugier R

更新日期：2002-01-01 00:00:00

abstract：AIMS:We investigated the effect of n-3 polyunsaturated fatty acids (PUFAs) on mucosal levels of leukotrienes (LTs) and lipid peroxide (LPO), and on mucosal microcirculation, in rats with experimental colitis induced by dextran sulfate sodium (DSS). METHODS:We fed Wistar rats a perilla oil-enriched diet containing alph...

journal_title：Digestion

authors： Shimizu T,Igarashi J,Ohtuka Y,Oguchi S,Kaneko K,Yamashiro Y

更新日期：2001-01-01 00:00:00

abstract：:We have previously shown a specific significant overexpression in the exocrine pancreatic tissue of two members of the regenerating gene multifamily: reg I and reg II in the non-obese diabetic (NOD) mouse during active diabetogenesis. To strengthen the hypothesis that the overexpression of these genes may represent a ...

journal_title：Digestion

authors： Baeza N,Sanchez D,Christa L,Guy-Crotte O,Vialettes B,Figarella C

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:gamma delta T cell populations are well-known for their unique distribution (e.g. intra-epithelial lymphocytes). Though their ligands play a major role in the immune response they have remained largely obscure. To shed light on this issue, we have analyzed in this study the complementarity det...

journal_title：Digestion

authors： Ishiguro Y,Kanazawa H,Yamagata K,Sakuraba H,Munakata A

更新日期：2001-01-01 00:00:00

abstract：:Recently our studies have demonstrated that the central nervous system regulates in part mucosal cell growth and apoptosis in the rat small intestine. Ornithine decarboxylase (ODC) activity is a key enzyme for polyamine synthesis which plays an important role for the intestinal mucosal growth. We have demonstrated tha...

journal_title：Digestion

authors： Fujimoto K,Iwakiri R,Utsumi H,Kojima M,Ishibashi S,Wu B,Sakata H,Noda T

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND/AIMS:Early weaning has been shown to induce intestinal ornithine decarboxylase (ODC) activities and cell proliferation in rats. No information is available about the effect of early weaning on ODC activity in the stomach. METHODS:Suckling rats were prematurely weaned on postnatal day 15 and followed through...

journal_title：Digestion

authors： Lin CH,Lyons H,Seelbach MS,Tolia V,Vijesurier R

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND/AIMS:L-glutamine (L-gln) is a conditionally essential amino acid which is consumed by certain tissues like the intestine in large amounts as energy source during critical illness. Apart from nutritive action, recent data suggest a link to heat-shock protein (hsp) induction. We investigated the effect of L-gl...

journal_title：Digestion

authors： Lindemann G,Grohs M,Stange EF,Fellermann K

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND/AIMS:We have used the Zucker diabetic fatty (ZDF) rat to study the effects of type-2 diabetes and troglitazone on the small intestinal mucosal mass, sugar transporters and the peroxisomal proliferator-activated receptor, PPAR-gamma. METHODS:Age-matched ZDF and lean control (ZLC) rats were fed a standard cho...

journal_title：Digestion

authors： Corpe C,Sreenan S,Burant C

更新日期：2001-01-01 00:00:00